Theme of Research
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Specific responses of glial cells such as microglia (red) and astrocytes (green) to the amyloid pathology (blue) characteristic of Alzheimer’s disease.(Saito et al., Nat Neurosci. 2014)
Member
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Major research achievements
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Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease.
Nature Communications 15, 1323409 (2024) -
Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Nature Communications 10, 2394 (2019) -
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.
Journal of Biological Chemistry 294, 12754-12765 (2019) -
Calpain activation in Alzheimer's model mice is an artifact of APP and presenilin overexpression.
Journal of Neuroscience 36, 9933-9936 (2016) -
Single APP knockin mouse models of Alzheimer’ s disease.
Nature Neuroscience 17, 661-663 (2014) -
Potent amyloidogenicity and pathogenicity of Aβ43.
Nature Neuroscience 14, 1023-1032 (2011) -
Link to the original HP