When you think of memory systems in the brain, you may think they only store information from the past. In fact, however, the memory systems are critical to determine our future behavior based on the past. For example, the experience of studying hard and improving exam scores can lead to further study behavior. In contrast, the negative experience can reduce motivation for subsequent behavior and in some cases cause depression and post-traumatic stress disorder (PTSD). In addition, in dementia, the memory system in the brain does not work properly, making it impossible to perform normal daily activities. Our missions are to elucidate the neural mechanisms that regulate learning and memory and to develop how to treat memory-related psychiatric disorders.
Endowed Course Professor:
Hiroshi Nomura, Ph.D.
- Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories. Biol Psychiatry. 2019 Aug 1;86(3):230-239.
- Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits. Elife. 2015 Jul 30;4:e08274.
- Memory formation and retrieval of neuronal silencing in the auditory cortex. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9740-4.
- Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. J Neurosci. 2015 Jan 14;35(2):819-30.
- Frontal association cortex is engaged in stimulus integration during associative learning. Curr Biol. 2015 Jan 5;25(1):117-23.
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