Theme

While chemicals provide many benefits, many chemicals have adverse effects in some cases. Toxicology plays an important role in risk assessment of chemicals for carcinogenicity, neurotoxicity, reproductive toxicity, developmental toxicity, genetic toxicity, immunotoxicity and general toxicity. The risk assessment can help prevent health hazards and it is also utilized for risk management. In our laboratory, we are developing the method of risk assessment for new substances such as nanomaterials, which have different properties from general chemicals. In addition, we are developing new low-toxic anti-cancer drugs, which are derivatives of component from natural products, using in vitro, in vivo and in silico analyses. Associated with founding of the Institute of Brain Science, we will study wider research fields.

Scanning electron microscope image of multi-walled carbon nanotubes

Members

Professor
Masumi Suzui
Associate professor
Katsumi Fukamachi
Associate professor
Kenji Ono
Technical staff
Hideaki Kurachi

Publications

  • Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines. Int J Oncol 58: 251-265 (2021)
  • Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells. Nagoya J Med Sci 82: 509-518 (2020)
  • Evalution of a biomarker for the diagnosis of pancreas cancer using an animal model. J Toxicol Pathol 32: 135-141 (2019)
  • Persistent pleural lesions and inflammation by pulmonary exposure of multiwalled carbon nanotubes. Chem Res Toxicol 31: 1025-1031 (2018)
  • Therapeutic and preventive effects of osteoclastogenesis inhibitory factor on osteolysis, proliferation of mammary tumor cell and induction of cancer stem cells in the bone microenvironment. Int J Mol Sci 19: 888 (2018)
  • Lethal chronotoxicity induced by seven metal compounds in mice. J Toxicol Sci 43: 129-134 (2018)